Reaction #74339

ord-0a372de55e6d4838ab696f31c334e569

Reaction equation

N[C@@H](Cc1ccc(O)cc1)C(=O)O
(2S)-2-amino-3-(4-hydroxyphenyl)propanoicacid
NC(=S)NC1CCCCCC1
N-cycloheptylthiourea
→
O=C1N=C(NC2CCCCCC2)SC1Cc1ccc(O)cc1
2-(cycloheptylamino)-5-(4-hydroxybenzyl)-1,3-thiazol-4(5H)-one

Reactants

N[C@@H](Cc1ccc(O)cc1)C(=O)O
(2S)-2-amino-3-(4-hydroxyphenyl)propanoicacid
NC(=S)NC1CCCCCC1
N-cycloheptylthiourea

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherSynthesis

Procedure

Synthesis was performed from (2S)-2-amino-3-(4-hydroxyphenyl)propanoicacid and N-cycloheptylthiourea according to Method E and C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541592B2uspto-grants-2013_09