Reaction #74338

ord-55e3372f8d4f4f12885fdd0281818d42

Reaction equation

N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid
NC(=S)NC1CCCCCC1
N-cycloheptylthiourea
→
O=C1N=C(NC2CCCCCC2)SC1Cc1c[nH]c2ccccc12
2-(cycloheptylamino)-5-(1H-indol-3-ylmethyl)-1,3-thiazol-4(5H)-one

Reactants

N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid
NC(=S)NC1CCCCCC1
N-cycloheptylthiourea

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherSynthesis

Procedure

Synthesis was performed from (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid and N-cycloheptylthiourea according to Method E and C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541592B2uspto-grants-2013_09