Reaction #74324

ord-8d54337e7e3d416cbb32fe00886770cc

Reaction equation

NC(=S)NC1CC2CCC1C2
N-bicyclo[2.2.1]hept-2-ylthiourea
CCOC(=O)C1(Br)CCC1
ethyl 1-bromocyclobutanecarboxylate
→
O=C1N=C(NC2CC3CCC2C3)SC12CCC2
6-(Bicyclo[2.2.1]hept-2-ylamino)-5-thia-7-azaspiro[3.4]oct-6-en-8-one

Reactants

NC(=S)NC1CC2CCC1C2
N-bicyclo[2.2.1]hept-2-ylthiourea
CCOC(=O)C1(Br)CCC1
ethyl 1-bromocyclobutanecarboxylate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherSynthesis

Procedure

Synthesis was performed from N-bicyclo[2.2.1]hept-2-ylthiourea and ethyl 1-bromocyclobutanecarboxylate according to Method D.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541592B2uspto-grants-2013_09