Reaction #742300

Reaction equation

3-Hydroxybenzylamine

sodium hydrogen carbonate

phenyl chloroformate

→

titled compound

(3-Hydroxy-benzyl)-carbamic acid phenyl ester

Solvents

water DCM

DCM water

Conditions

Workup

1. 1
   Otherthe organic phase is separated
2. 2
   ConcentrationThe organic portion is concentrated in vacuo

Procedure

3-Hydroxybenzylamine (200 mg, 1.62 mmol) and sodium hydrogen carbonate (273 mg, 3.25 mmol) suspended in water/DCM (4 mL, 1:1) is treated with phenyl chloroformate (0.204 mL, 1.62 mmol). After stirring at RT overnight, the reaction mixture is diluted with more DCM/water and the organic phase is separated. The organic portion is concentrated in vacuo to afford the titled compound. (MH+244)

Source