Reaction #742275

ord-f8e857b323dc4f299eb3c868e4ea4e32

Reaction equation

N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ccccc1
cefaclor
N
ammonia
→
N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ccccc1.O
cefaclor monohydrate

Reactants

N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ccccc1
cefaclor
N
ammonia

Reagents

None

Solvents

O
water

Conditions

Temperature
10°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    FiltrationThe suspension was filtered through a glass
  2. 2
    Filtrationfilter
  3. 3
    Washthe wet cake was washed with 2×15 ml water and 2×15 ml acetone
  4. 4
    OtherAfter drying

Procedure

A crystallisation reactor was filled with 10 g water. The above-mentioned acidic cefaclor solution was dosed into the crystallisation reactor in 30 minutes at 25° C. The pH was kept at 5.0 with ammonia. Subsequently, the suspension was stirred at 10° C. for another 30 min. The suspension was filtered through a glass filter and the wet cake was washed with 2×15 ml water and 2×15 ml acetone. After drying, 18.3 g cefaclor monohydrate was obtained (purity 99.6%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08071330B2uspto-grants-2011_12