Reaction #73635
ord-21b509c3d6944a42a73670d742415383
Reaction equation
4-methoxybenzoyl chloride
2-amino-4-methylthiazole-5-carboxylic acid benzylamide
→
title compound
Yield 10.0%
2-(4-Methoxybenzoylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide
Yield 10.0%
Reagents
None
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Procedure
Following the procedure as described in Example 2, making variations only as required to use 4-methoxybenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 10% yield; m.p. 203-204° C.; 1H NMR (CDCl3, 300 MHz) δ 7.86 (d, J=8.8 Hz, 2H), 7.35-7.30 (m, 5H), 6.96 (d, J=8.8 Hz, 2H), 5.97 (t, J=5.6 Hz, 1H), 4.58 (d, J=5.6 Hz, 2H), 3.86 (s, 3H), 2.49 (s, 3H); MS (ES+) m/z 382.1 (M+1).