Reaction #73583

Reaction equation

potassium hydroxide

metformin hydrochloride

acetic acid

→

metformin acetate

Yield 58.2%

Solvents

water

Conditions

Workup

1. 1
   workup.DISSOLUTIONto dissolve thoroughly
2. 2
   FiltrationThe resulting crystal was filtered
3. 3
   Washwashed with acetone
4. 4
   Otherdried at 60° C.

Procedure

20.0 g (1 equivalent) of metformin hydrochloride and 50 Ml of water, and then 10 Ml (1.45 equivalents) of glacial acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 10.2 g (1.5 equivalents) of aqueous solution of potassium hydroxide were added to the reaction solution. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 13.3 g of metformin acetate (yield: 58.2%).

Source