Reaction #73578

ord-8f6f02ec54e8446e91f4b5525381d122

Reaction equation

CN(C)C(=N)N=C(N)N.Cl
metformin hydrochloride
CC(=O)[O-].O.O.O.[Na+]
sodium acetate trihydrate
→
CC(=O)[O-].CN(C)C(=N)NC(=N)N
metformin acetate
Yield 51.6%

Reactants

CN(C)C(=N)N=C(N)N.Cl
metformin hydrochloride
CC(=O)[O-].O.O.O.[Na+]
sodium acetate trihydrate

Reagents

None

Solvents

O
water

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    FiltrationThen the resulting crystal was filtered
  2. 2
    Washwashed with acetone
  3. 3
    Otherdried at 60° C.

Procedure

20.0 g (1 equivalent) of metformin hydrochloride, 50 Ml of water, and 19.72 g (1.2 equivalents) of sodium acetate trihydrate were added to a reactor, and stirred. Then the resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 11.72 g of metformin acetate (yield: 51.3%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541474B2uspto-grants-2013_09