Reaction #731583

Reaction equation

Ethanol

2-benzyloxy-5-cyanobenzoic acid benzyl ester

→

title compound

Yield 100.0%

5-Cyanosalicylic acid

Yield 100.0%

Solvents

tetrahydrofuran

Conditions

Workup

1. 1
   FiltrationAfter the insoluble matter was filtered off
2. 2
   Otherthe solvent was evaporated under reduced pressure

Procedure

Ethanol (10 mL) and tetrahydrofuran (10 mL) were added to 2-benzyloxy-5-cyanobenzoic acid benzyl ester (446 mg, 1.3 mmol) and 5% palladium on carbon (45 mg), and the mixture was hydrogenated at room temperature for 2 hours. After the insoluble matter was filtered off, the solvent was evaporated under reduced pressure to give the title compound (212 mg, 100.0%) as a white solid.

Source