Reaction #72924

Reaction equation

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

Yield 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

Yield 83.0%

Solvents

ethanol

Conditions

Workup

1. 1
   TemperatureThe resulting solution was refluxed for 6 hours
2. 2
   OtherThe solvent was then removed in vacuo
3. 3
   Otherthe residue partitioned between dichloromethane and water
4. 4
   DryingThe organic layer was dried over sodium sulfate
5. 5
   Otherevaporated to dryness

Procedure

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

Source