Reaction #722528

Reaction equation

1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide

→

3-[1-(3,4-dichlorophenyl)cyclobutyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine hydrobromide

Solvents

acetic acid

Conditions

Workup

1. 1
   Otherprepared in a manner similar to
2. 2
   Temperaturewas heated
3. 3
   Temperatureunder reflux for 16 hours
4. 4
   OtherThe solvent was removed in vacuo
5. 5
   Otherthe residue was triturated with ether (50 ml)
6. 6
   Filtrationthe resulting solid was collected by filtration
7. 7
   Washwashed with ether (50 ml)
8. 8
   Otherdried in vacuo at ambient temperature

Procedure

A suspension of 1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide (2.0 g—prepared in a manner similar to that described above) in acetic acid (7 ml) was heated under reflux for 16 hours, then allowed to cool to ambient temperature. The solvent was removed in vacuo, the residue was triturated with ether (50 ml), and the resulting solid was collected by filtration, washed with ether (50 ml), and dried in vacuo at ambient temperature to give 3-[1-(3,4-dichlorophenyl)cyclobutyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine hydrobromide as a white solid (1.7 g), m.p. 269° C.

Source