Reaction #722527

Reaction equation

2-bromo-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethanone

3,4,5,6-tetrahydropyrimidine-2-thiol

→

1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide

Yield 89.6%

Solvents

acetone

acetone

Conditions

Workup

1. 1
   Temperaturethe mixture was heated
2. 2
   Temperatureunder reflux for 0.5 hour
3. 3
   FiltrationThe resulting solid was collected by filtration
4. 4
   Otherdried in vacuo at ambient temperature

Procedure

A solution of 2-bromo-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethanone (3.2 g) in acetone (25 ml) was added to a solution of 3,4,5,6-tetrahydropyrimidine-2-thiol (1.2 g) in acetone (150 mL), then the mixture was heated under reflux for 0.5 hour, and allowed to cool to ambient temperature. The resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide as a white solid (3.9 g), m.p. 203-204° C.

Source