Reaction #722524

Reaction equation

2-bromo-1-[1-(4-chlorophenyl)cyclobutyl]ethanone

3,4,5,6-tetrahydropyrimidine-2-thiol

→

1-[1-(4-chlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide

Yield 86.0%

Solvents

acetone

acetone

Conditions

Workup

1. 1
   Temperaturethe mixture was heated
2. 2
   Temperatureunder reflux for 1 hour
3. 3
   FiltrationThe resulting solid was collected by filtration
4. 4
   Otherdried in vacuo at ambient temperature

Procedure

A solution of 2-bromo-1-[1-(4-chlorophenyl)cyclobutyl]ethanone (2.9 g) in acetone (25 ml) was added to a solution of 3,4,5,6-tetrahydropyrimidine-2-thiol (1.2 g) in acetone (150 ml), then the mixture was heated under reflux for 1 hour, and allowed to cool to ambient temperature. The resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 1-[1-(4-chlorophenyl)cyclobutyl]-2-(3,4,5,6-tetrahydropyrimidin-2-ylthio)ethanone hydrobromide as a white solid (3.5 g), m.p. 205° C.

Source