Reaction #722521

Reaction equation

1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(2-imidazolin-2-ylthio)ethanone hydrobromide

→

3-[1-(3,4-dichlorophenyl)cyclobuty]-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

Yield 94.0%

Solvents

acetic acid

Conditions

Workup

1. 1
   Temperaturewas heated
2. 2
   Temperatureunder reflux for 18 hours
3. 3
   OtherThe solvent was removed in vacuo
4. 4
   Otherthe resulting solid was triturated with ether (50 ml)
5. 5
   Filtrationcollected by filtration
6. 6
   Washwashed with ether (50 ml)
7. 7
   Otherdried in vacuo at 50° C. for 3 hours

Procedure

A stirred suspension of 1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-(2-imidazolin-2-ylthio)ethanone hydrobromide (5 g) in acetic acid (20 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The solvent was removed in vacuo, the residue was allowed to stand at ambient temperature for 24 hours, and the resulting solid was triturated with ether (50 ml), collected by filtration, washed with ether (50 ml) and dried in vacuo at 50° C. for 3 hours to give 3-[1-(3,4-dichlorophenyl)cyclobuty]-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide as a white solid (4.5 g), m.p. 241-244° C.

Source