Reaction #722385

ord-36f6c2358b8b4e43b2e3adab177400ea

Reaction equation

CCCOc1ccc(S(=O)(=O)N2CCOCC2)cc1-c1nc2c(Br)cccc2c(=O)[nH]1
2-(2-n-propoxy-5-morpholinosulfonylphenyl)-8-bromoquinazolin-4(3H)-one
C=CCCCCC
1-heptene
CCCCCC=Cc1cccc2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCOCC4)ccc3OCCC)nc12
title compound
Yield 53.2%
CCCCCC=Cc1cccc2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCOCC4)ccc3OCCC)nc12
2-(2-n-Propoxy-5-Morpholinosulfonylphenyl)-8-(1-Hepten-1-yl)Quinazolin-4(3H)-One
Yield 53.2%

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound is prepared analogously to the method of Example 1, starting with 2-(2-n-propoxy-5-morpholinosulfonylphenyl)-8-bromoquinazolin-4(3H)-one and 1-heptene.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06187779B1uspto-grants-2001_02