Reaction #721759

ord-1a64d894295d4410a6951a4fe8e69ebe

Reaction equation

O.OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose monohydrate
→
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
Lactose

Reactants

O.OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose monohydrate

Reagents

None

Solvents

FC(F)(Cl)C(F)(Cl)Cl
CFC-113

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherwas mounted in the driving chuck of an electric motor at 45°
  2. 2
    OtherThis arrangement gave the required flow pattern in which the powder

Procedure

Micronised lactose monohydrate (50 g) was placed in a cylindrical glass pelletising pan of 160 mm diameter and 80 mm depth, tapering towards entry, with an axial driving spindle mounted on the flat base. The pan was mounted in the driving chuck of an electric motor at 45° to the vertical and run at 30 rpm (peripheral angular velocity=0.25 ms−1). This arrangement gave the required flow pattern in which the powder climbed and then flowed down over a wide region of the flat base of the pan. A coarse liquid spray of CFC-113 (30 ml) was generated with a “Polyspray 2” (Hozelock) spray gun after pressurising the tank initially with 60 actuations of the hand air pump. The pellets were tumbled for 5 minutes in the closed pan and then immediately stored over silica gel.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06183782B2uspto-grants-2001_02