Reaction #7216

Reaction equation

4-trifluoromethyl-1H-imidazole

NaH

SEMCl

→

title compound

4-Trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

Conditions

Procedure

Reaction of 4-trifluoromethyl-1H-imidazole (301 mg, 2.21 mmol), 95% NaH (61 mg, 2.4 mmol), and SEMCl (406 mg, 2.44 mmol) gave the title compound as a brown oil that was used without further purification. 1H NMR (CDCl3) □ 0.00 (s, 9H), 0.93 (m, 2H), 3.51 (m, 2H), 5.30 (s, 2H), 7.39 (s, 1H), 7.64 (s, 1H).

Source