Reaction #72061

Reaction equation

cesium carbonate

benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride

methyl 5-bromo-2-fluorobenzoate

BINAP

→

title compound

Yield 14.4%

Methyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-fluorobenzoate

Yield 14.4%

Conditions

Procedure

The same operation as in Example (42a) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (165 mg, 0.55 mmol), methyl 5-bromo-2-fluorobenzoate (128 mg, 0.55 mmol), palladium acetate (12.3 mg, 0.05 mmol), BINAP (68.3 mg, 0.11 mmol) and cesium carbonate (536 mg, 1.65 mmol), to obtain 33 mg of the title compound as a yellow oily substance (14%).

Source