Reaction #71751

Reaction equation

ammonia

NCS

2,2,2-trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone

2,2,2-Trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone

dimethoxyacetaldehyde

→

2-(Dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

Conditions

Workup

1. 1
   OtherThe resulting compound was used for the next reaction without purification

Procedure

The same operation as in Example (36b) was performed using NCS (1.35 g, 10.1 mmol), silver nitrate (2.45 g, 14.4 mmol), 2,2,2-trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone obtained in Example (39b) (1.0 g, 4.09 mmol), dimethoxyacetaldehyde (5.76 M aqueous solution, 1.0 mL, 5.76 mmol) and 28% aqueous ammonia (4 mL). The resulting compound was used for the next reaction without purification.

Source