Reaction #71665

Reaction equation

2-methyl-3-pyridinecarboxylic acid

thionyl chloride

→

title compound

Yield 100.0%

2-methyl-3-pyridinecarbonyl chloride

Yield 100.0%

Conditions

Workup

1. 1
   ConcentrationThe reaction was concentrated under reduced pressure

Procedure

2-methyl-3-pyridinecarboxylic acid (20 g, 146 mmol) was dissolved in thionyl chloride (60 ml, 822 mmol) and stirred at room temperature for 24 h. The reaction was concentrated under reduced pressure, to obtain the title compound as a white solid (28.1 g, 146 mmol). Acyl chloride was checked by quenching a sample in MeOH, LCMS showed methyl ester derivative. {[M+H]+=152}

Source