Reaction #71396

Reaction equation

8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid

3-aminopyridine

→

title compound

8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid pyridin-3-ylamide

Conditions

Workup

1. 1
   OtherThe crude product was purified by silica gel column chromatography (DCM/MeOH/NH3aq, 96:3:1)

Procedure

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (Step 88.1), 3-aminopyridine, and stirring the reaction mixture for 72 h at rt. The crude product was purified by silica gel column chromatography (DCM/MeOH/NH3aq, 96:3:1) followed by trituration in Et2O. Title compound: ESI-MS: 423.1 [M+H]+; tR=3.53 min (System 1); TLC: Rf=0.56 (DCM/MeOH/NH3aq, 96:3:1).

Source