Reaction #71333

Reaction equation

4-(4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

→

title compound

Yield 96.7%

4-(4-Amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Yield 96.7%

Solvents

MeOH

Conditions

Workup

1. 1
   FiltrationThe reaction mixture was filtered through a pad of celite
2. 2
   Concentrationconcentrated

Procedure

A suspension of 4-(4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (Step 8.3) (1.26 g, 4.1 mmol) and palladium on carbon (200 mg) in MeOH (30 mL) was stirred for 30 min at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 1.1 g of the title compound as a pink solid: ESI-MS: 278.2 [M+H]+; tR=2.85 min (System 1).

Source