Reaction #710584

Reaction equation

2-chloro-quinolin-8-ol

pyrazole

→

2-pyrazol-1-yl-quinolin-8-ol

Conditions

Workup

1. 1
   OtherThe crude product was then purified by column chromatography on silica (ethyl acetate/hexane, 1:1)

Procedure

A mixture of 2-chloro-quinolin-8-ol 3 (80 mg, 0.447 mmol) and pyrazole (152 mg, 2.233 mmol) was heated at 175° C. in a steel autoclave for 48 h. The crude product was then purified by column chromatography on silica (ethyl acetate/hexane, 1:1) to give 2-pyrazol-1-yl-quinolin-8-ol (compound ID 964) I1 as a white solid (68 mg, 72%).

Source