Reaction #710582

Reaction equation

8-Hydroxy-quinoline-2-carboxaldehyde oxime

→

2-aminomethyl-quinolin-8-ol

Yield 82.0%

Solvents

MeOH

Conditions

Workup

1. 1
   Filtrationthe catalyst was filtered off
2. 2
   Otherthe volatiles removed which

Procedure

8-Hydroxy-quinoline-2-carboxaldehyde oxime D1 (167 mg, 0.888 mmol) and MeOH (50 mL) was treated under hydrogenolysis conditions (atmospheric H2, catalytic 10% Pd/carbon) at RT. After 4 h, the catalyst was filtered off and the volatiles removed which afforded 2-aminomethyl-quinolin-8-ol E1 as a light brown solid (126 mg, 82%); spectral data of this compound are given in Table 2.

Source