Reaction #710564

ord-c37ad968adb54e5184cc8eb625203d11

Reaction equation

O=S(=O)(Cl)c1ccc(-c2ccc(F)cc2F)cc1
2′,4′-difluorobiphenyl-4-sulfonyl chloride
COC(=O)[C@H]1CC[C@H](N)CC1
methyl trans-4-aminocyclohexanecarboxylate
→
COC(=O)[C@H]1CC[C@H](NS(=O)(=O)c2ccc(-c3ccc(F)cc3F)cc2)CC1
title compound
COC(=O)[C@H]1CC[C@H](NS(=O)(=O)c2ccc(-c3ccc(F)cc3F)cc2)CC1
Methyl 4-(2′,4′-difluorobiphenyl-4-ylsulfonamido)trans-cyclohexanecarboxylate

Reactants

O=S(=O)(Cl)c1ccc(-c2ccc(F)cc2F)cc1
2′,4′-difluorobiphenyl-4-sulfonyl chloride
COC(=O)[C@H]1CC[C@H](N)CC1
methyl trans-4-aminocyclohexanecarboxylate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Using a method analogous to Method A with 2′,4′-difluorobiphenyl-4-sulfonyl chloride and methyl trans-4-aminocyclohexanecarboxylate, the title compound was obtained as a white solid.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09302984B2uspto-grants-2016_04