Reaction #710563

ord-e73ebdab53a843a9b4badb17a3c8f8fc

Reaction equation

COC(=O)[C@@H]1CC[C@H](N)C1
(1R,3S)-methyl 3-aminocyclopentanecarboxylate
O=S(=O)(Cl)c1ccc(-c2ccc(F)cc2F)cc1
2′,4′-difluorobiphenyl-4-sulphonyl chloride
→
COC(=O)[C@@H]1CC[C@H](NS(=O)(=O)c2ccc(-c3ccc(F)cc3F)cc2)C1
title compound
COC(=O)[C@@H]1CC[C@H](NS(=O)(=O)c2ccc(-c3ccc(F)cc3F)cc2)C1
(1R,3S)-Methyl 3-(2′,4′-difluorobiphenyl-4-ylsulfonamido)cyclopentanecarboxylate

Reactants

COC(=O)[C@@H]1CC[C@H](N)C1
(1R,3S)-methyl 3-aminocyclopentanecarboxylate
O=S(=O)(Cl)c1ccc(-c2ccc(F)cc2F)cc1
2′,4′-difluorobiphenyl-4-sulphonyl chloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Using a method analogous to Method A, using (1R,3S)-methyl 3-aminocyclopentanecarboxylate and 2′,4′-difluorobiphenyl-4-sulphonyl chloride, the title compound was obtained as a pale yellow gum.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09302984B2uspto-grants-2016_04