Reaction #710503

ord-09beeee2505841458329c4dc2d85ed28

Reaction equation

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

Reactants

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

Reagents

None

Solvents

O
water
O
water

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherreaction
  2. 2
    Otherfor the reaction
  3. 3
    OtherCarbon dioxide is evaporated rapidly
  4. 4
    Otherwater is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    OtherThe product is then dried
  7. 7
    Othercrushed to fine particles
  8. 8
    Otherto produce an active composition suitable for formulation into the pharmacological formulations of this invention

Procedure

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09301935B2uspto-grants-2016_04