Reaction #710481

Reaction equation

2-chloro-5-chloromethyl pyridine

2-aminopyrimidine

→

1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-imine hydrochloride

Yield 34.0%

Solvents

DMF

Conditions

Workup

1. 1
   Otherwas returned to room temperature
2. 2
   workup.DISTILLATIONto distill off DMF under reduced pressure
3. 3
   workup.ADDITIONDiethyl ether was added
4. 4
   Otherthus crystallization
5. 5
   Otherwas occurred on the wall surface of an eggplant flask
6. 6
   OtherDiethyl ether was removed by decantation
7. 7
   Otherdried well

Procedure

300 mg (1.86 mmol) of 2-chloro-5-chloromethyl pyridine was dissolved in 6 ml of anhydrous DMF, 118 mg (1.24 mmol) of 2-aminopyrimidine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the reaction solution was returned to room temperature to distill off DMF under reduced pressure. Diethyl ether was added thereto, and thus crystallization was occurred on the wall surface of an eggplant flask. Diethyl ether was removed by decantation and dried well to obtain 1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-imine hydrochloride. Amount obtained 107 mg (yield 34%)

Source