Reaction #70990

ord-a8f52c7e30104d33aca8e437c6c400a1

Reaction equation

O=CCCc1nc(-c2ccccc2)c(-c2ccccc2)o1
3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanal
Cl.NOCc1ccccc1
O-benzylhydroxylamine hydrochloride
C(CCc1nc(-c2ccccc2)c(-c2ccccc2)o1)=NOCc1ccccc1
title compound
C(CCc1nc(-c2ccccc2)c(-c2ccccc2)o1)=NOCc1ccccc1
3-(4,5-Diphenyl-1,3-oxazol-2-yl)-propionaldehyde O-benzyl-oxime

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The process described in Method A was followed. 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanal (416 mg, 1.5 mmol, see Pridgen L. N. et al in Tetrahedron Lett., 25(27), 2835 (1984)) and O-benzylhydroxylamine hydrochloride (319 mg, 2.0 mmol) were used to obtain the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536210B2uspto-grants-2013_09