Reaction #70830

Reaction equation

tert-butyl (±)-(cis)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclobutylcarbamate

dioxane

→

title compound

((±)-(cis)-2-Aminocyclobutyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride

Solvents

HCl

Conditions

Workup

1. 1
   ConcentrationAfter this time, the mixture was concentrated in vacuo
2. 2
   Concentrationconcentrated 3× from methylene chloride
3. 3
   Otherto remove residual HCl and dioxane

Procedure

A solution of tert-butyl (±)-(cis)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclobutylcarbamate (160 mg, 0.366 mmol) in 4 M HCl in dioxane (5 mL, 20.00 mmol HCl) was stirred at room temperature for 3 hours. After this time, the mixture was concentrated in vacuo, then concentrated 3× from methylene chloride to remove residual HCl and dioxane, to yield the title compound as a colorless solid which was used without purification in the next step. MS (ESI+)=327.3 (M+H)+.

Source