Reaction #70338

ord-90ce822ad7ce44f6b939fadafdf54175

Reaction equation

Cc1ccc(Nc2cnc(-c3ccccc3)c(Cl)c2)c(C(=O)OC(C)(C)C)c1
tert-Butyl 2-(5-chloro-6-phenylpyridin-3-ylamino)-5-methylbenzoate
→
Cc1ccc(Nc2cnc(-c3ccccc3)c(Cl)c2)c(C(=O)O)c1
2-(5-Chloro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid

Reactants

Cc1ccc(Nc2cnc(-c3ccccc3)c(Cl)c2)c(C(=O)OC(C)(C)C)c1
tert-Butyl 2-(5-chloro-6-phenylpyridin-3-ylamino)-5-methylbenzoate

Reagents

None

Solvents

O=C(O)C(F)(F)F
TFA

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherObtained
  2. 2
    Other(0.005 g, 87% of yield)

Procedure

Obtained (0.005 g, 87% of yield) following the procedure described in Example 8 (step B) starting with 0.006 g (0.02 mmol) of tert-Butyl 2-(5-chloro-6-phenylpyridin-3-ylamino)-5-methylbenzoate in 1 ml of TFA.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536165B2uspto-grants-2013_09