Reaction #70336

Reaction equation

tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate

→

expected product

2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid

Solvents

TFA

Conditions

Workup

1. 1
   Otherthe crude mixture was purified by reverse phase chromatography
2. 2
   Otheraffording

Procedure

A solution of tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate (0.83 mmol, 0.313 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.119 g (40% of yield) of the expected product.

Source