Reaction #70293

ord-33a4b93db77a4bf6a6afdfbf2888e006

Reaction equation

Cc1cc(Br)cnc1Br
2,5-dibromo-3-methylpyridine
CCOc1cccc(B(O)O)c1
3-ethoxyphenylboronic acid
CCOc1cccc(-c2ncc(Br)cc2C)c1
5-Bromo-2-(3-ethoxyphenyl)-3-methylpyridine
Yield 37.0%

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherObtained (1.30 g, yield 37%)

Procedure

Obtained (1.30 g, yield 37%) following the procedure described in Intermediate 27, starting with 2,5-dibromo-3-methylpyridine (11.96 mmol, 3.0 g), 3-ethoxyphenylboronic acid (11.96 mmol, 1.98 g).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536165B2uspto-grants-2013_09