Reaction #70210

Reaction equation

3′-Hydroxyacetophenone

compound 19

O-(4-Nitrobenzyl)hydroxylamine Hydrochloride

→

CP30260

Yield 82.0%

(E)-3′-Hydroxyacetophenone O-4-Nitrobenzyl Oxime

Yield 82.0%

Conditions

Workup

1. 1
   TemperatureAfter being heated for 3 h the reaction mixture
2. 2
   Temperaturewas cooled
3. 3
   Otherthe solvent removed under reduced pressure
4. 4
   FiltrationThe resulting solid was filtered off
5. 5
   Washwashed with cold isopropanol (3.0 mL)

Procedure

3′-Hydroxyacetophenone (24) (150 mg, 1.10 mmol) was condensed with compound 19 (248 mg, 1.21 mmol) according to the general procedure II-A defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The resulting solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30260 (257 mg, 82%) as a white solid, m.p. 123.6-125.3° C.

Source