Reaction #70206

Reaction equation

4′-Methoxyacetophenone

compound 19

O-(4-Nitrobenzyl)hydroxylamine Hydrochloride

→

CP30253

Yield 68.0%

(E)-4′-Methoxyacetophenone O-4-Nitrobenzyl Oxime

Yield 68.0%

Conditions

Workup

1. 1
   TemperatureAfter heating the reaction mixture for 2 h it
2. 2
   Temperaturewas cooled
3. 3
   Filtrationthe resulting solid filtered off
4. 4
   Washwashed with cold isopropanol (3.0 mL)

Procedure

4′-Methoxyacetophenone (21) (150 mg, 1.00 mmol) was condensed with compound 19 (225 mg, 1.10 mmol) according to the general procedure II-A defined above. After heating the reaction mixture for 2 h it was cooled and the resulting solid filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30253 (204 mg, 68%) as a pale-yellow solid, m.p. 88.2-89.5° C.

Source