Reaction #70205

Reaction equation

Acetophenone

compound 19

O-(4-Nitrobenzyl)hydroxylamine Hydrochloride

→

CP30252

Yield 77.0%

(E)-Acetophenone O-4-Nitrobenzyl Oxime

Yield 77.0%

Conditions

Workup

1. 1
   TemperatureAfter heating the reaction mixture for 2 h it
2. 2
   Temperaturewas cooled
3. 3
   Otherthe solvent removed under reduced pressure
4. 4
   FiltrationThe resulting solid was filtered off
5. 5
   Washwashed with cold isopropanol (3.0 mL)

Procedure

Acetophenone (20) (150 mg, 1.25 mmol) was condensed with compound 19 (280 mg, 1.37 mmol) according to the general procedure II-A defined above. After heating the reaction mixture for 2 h it was cooled and the solvent removed under reduced pressure. The resulting solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30252 (258 mg, 77%) as a pale-yellow solid, m.p. 91.3-92.3° C.

Source