Reaction #7012

Reaction equation

hydrazine

tert-butyl malonate

1-hydroxybenzotriazole hydrate

triethylamine

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

→

title compound

3-Oxo-3-[N′-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carbonyl)-hydrazino]-propionic acid tert-butyl ester

Solvents

dichloromethane

dichloromethane

Conditions

Workup

1. 1
   Washwashed with water (150 ml)
2. 2
   Dryingdried (MgSO4)
3. 3
   Otherevaporated under reduced pressure
4. 4
   OtherThe residual oil was purified by column chromatography on silica gel

Procedure

A mixture of the hydrazine from preparation 35 (2.2 g, 10 mmol), tert-butyl malonate (1.6 g, 10 mmol), 1-hydroxybenzotriazole hydrate (2.02 g, 15 mmol), triethylamine (4.8 ml, 20 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.4 g, 12.5 mmol) in dichloromethane (50 ml) was stirred at room temperature for 5 hours. The reaction was diluted with dichloromethane (200 ml), washed with water (150 ml), dried (MgSO4) and evaporated under reduced pressure. The residual oil was purified by column chromatography on silica gel using ethyl acetate as eluant to afford the title compound, as a white solid, 1.4 g.

Source