Reaction #696699

Reaction equation

NaOH

3-(2-biphenylyl)-2-ethylpropionic acid

thionyl chloride

→

crude product

Yield 106.3%

3-(2-biphenylyl)-2-ethylpropionyl chloride

Yield 106.3%

Conditions

Workup

1. 1
   OtherTo a 100-ml three-necked round flask (equipped with a stirrer tip
2. 2
   Temperaturewere refluxed for 2.5 hours
3. 3
   Temperaturewith heating in a nitrogen atmosphere
4. 4
   workup.DISTILLATIONthe unreacted thionyl chloride was distilled off under reduced pressure

Procedure

To a 100-ml three-necked round flask (equipped with a stirrer tip, a Dimroth condenser, a thermometer and a trap of NaOH) were introduced 13.3 g (52.4 mmol) of 3-(2-biphenylyl)-2-ethylpropionic acid and 25.9 ml (355 mmol) of thionyl chloride, and they were refluxed for 2.5 hours with heating in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 15.2 g of a crude product as a yellow orange liquid. This acid chloride was used for the next reaction without further purification. The properties of the product thus obtained are described below.

Source