Reaction #696695

Reaction equation

1,4-diaminobutane

triethylamine

2-chloro-2-methyl-3-nitrosopentane

→

2-(4-aminobutyl)amino-2-methyl-3-pentanone oxime

Solvents

acetonitrile

acetonitrile

Conditions

Workup

1. 1
   Otherto precipitate
2. 2
   workup.STIRRINGThe reaction mixture was stirred overnight
3. 3
   Filtrationthe product was filtered off
4. 4
   Otherdried in vacuo
5. 5
   Otherto give a white powder, (0.5 g; 86%)

Procedure

To a stirred solution of 1,4-diaminobutane (0.26 g; 2.9 mmol) and triethylamine (0.33 g; 3.2 mmol) in acetonitrile (5 ml) was added a solution of 2-chloro-2-methyl-3-nitrosopentane (0.485 g; 3.24 mmol) in acetonitrile (5 ml). After stirring for ca 10 minutes the product began to precipitate. The reaction mixture was stirred overnight and the product was filtered off and dried in vacuo to give a white powder, (0.5 g; 86%).

Source