Reaction #6960

Reaction equation

2,4-difluoro-5-nitrobenzoic acid

→

2,4-difluoro-5-aminobenzoic acid

Yield 97.6%

Solvents

ethanol

Conditions

Workup

1. 1
   Otherthe mixture was degassed
2. 2
   Filtrationfiltered
3. 3
   Concentrationthe filtrate was concentrated in vacuo

Procedure

To a solution of 2,4-difluoro-5-nitrobenzoic acid (0.998 g, 4.91 mmol) in ethanol (50 mL) was added 10% palladium on charcoal (107 mg) and the mixture was hydrogenated at 30 psi. After 2 h, the mixture was degassed, filtered and the filtrate was concentrated in vacuo to afford 2,4-difluoro-5-aminobenzoic acid (0.83 g, 97%) as tan solid. LC/MS (ESI); (M-H)−=172.

Source