Reaction #685004

Reaction equation

hydrogen chloride

1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine

→

achromatic crystal

1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine dihydrochloride

Solvents

ethyl acetate

ethyl acetate

Conditions

Workup

1. 1
   workup.ADDITIONwas added to the obtained solution
2. 2
   workup.WAITat 5° C. for 1 hour
3. 3
   OtherThereafter, precipitated crystals
4. 4
   Filtrationwere collected by filtration
5. 5
   WashThe crystals were washed with ethyl acetate
6. 6
   Otherdried

Procedure

0.39 g of 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine was dissolved in 4.0 ml of ethyl acetate. Thereafter, 0.80 ml of an ethyl acetate solution containing 3.25 mol/l dry hydrogen chloride was added to the obtained solution, and the mixture was stirred at a room temperature for 1 hour and then at 5° C. for 1 hour. Thereafter, precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate and then dried, so as to obtain 0.32 g of an achromatic crystal, 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine dihydrochloride.

Source