Reaction #685001

Reaction equation

oxalic acid

1-(2-(2-(1-benzothiophene-5-yl)ethoxy)ethyl)-3-pyrrolidinamine

→

achromatic crystal

Yield 89.6%

1-(2-(2-(1-benzothiophene-5-yl)ethoxy)ethyl)-3-pyrrolidinamine dioxalate

Yield 89.6%

Solvents

ethyl acetate

ethyl acetate

Conditions

Workup

1. 1
   workup.ADDITIONwas added to the obtained solution
2. 2
   workup.WAITat 5° C. for 1 hour
3. 3
   OtherThereafter, precipitated crystals
4. 4
   Filtrationwere collected by filtration
5. 5
   Washwashed with ethyl acetate
6. 6
   Otherdried

Procedure

0.71 g of 1-(2-(2-(1-benzothiophene-5-yl)ethoxy)ethyl)-3-pyrrolidinamine was dissolved in 3.0 ml of ethyl acetate. Thereafter, 4.0 ml of an ethyl acetate solution containing 0.44 g of oxalic acid was added to the obtained solution, and the obtained mixture was stirred at a room temperature for 1 hour and then at 5° C. for 1 hour. Thereafter, precipitated crystals were collected by filtration, washed with ethyl acetate, and then dried, so as to obtain 1.03 g of an achromatic crystal, 1-(2-(2-(1-benzothiophene-5-yl)ethoxy)ethyl)-3-pyrrolidinamine dioxalate.

Source