Reaction #684962

Reaction equation

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

Yield 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

Yield 72.6%

Solvents

tetrahydrofuran

methanol

Conditions

Workup

1. 1
   OtherThe catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   Otherprecipitates
4. 4
   Otherwere removed by filtration
5. 5
   Concentrationthe obtained filtrate was concentrated

Procedure

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

Source