Reaction #68149

Reaction equation

methyl 1-(2-(1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-ylamino)ethyl)-7-methoxy-2-oxo-1,2-dihydroquinoline-4-carboxylate

hydrogen chloride ethyl acetate

→

methyl 1-(2-(1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-ylamino)ethyl)-7-methoxy-2-oxo-1,2-dihydroquinoline-4-carboxylate hydrochloride

Solvents

ethyl acetate

Conditions

Workup

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   Filtrationthe resulting solid was filtered

Procedure

To 2 mL of an ethyl acetate solution containing 95 mg of methyl 1-(2-(1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-ylamino)ethyl)-7-methoxy-2-oxo-1,2-dihydroquinoline-4-carboxylate, 0.2 mL of 4.0 mol/L hydrogen chloride/ethyl acetate was added at room temperature, stirred at the same temperature for 10 min, and the resulting solid was filtered to give 84 mg of methyl 1-(2-(1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-ylamino)ethyl)-7-methoxy-2-oxo-1,2-dihydroquinoline-4-carboxylate hydrochloride as a yellow solid.

Source