Reaction #67871

ord-7f756c64875e4f958c08287c31129f23

Reaction equation

O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
O=C(O)c1ccncc1Nc1ccc(I)cc1F
intermediate 1
O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
NCc1cccc(O)c1
3-hydroxybenzylamine
O=C(NCc1cccc(O)c1)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]-N-(3-hydroxybenzyl)isonicotinamide

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherLC/MS [6.01 min; 464 (M+1)]

Procedure

3-[(2-fluoro-4-iodophenyl)amino]-N-(3-hydroxybenzyl)isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.22 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.35 mmol of 3-hydroxybenzylamine. LC/MS [6.01 min; 464 (M+1)]

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524911B2uspto-grants-2013_09