Reaction #67784

ord-831f693a9c4b4cb1b2a7ca46a2896ab2

Reaction equation

Nc1ccc(I)cc1Cl
2-chloro-4-iodoaniline
O=C(O)c1ccnc(F)c1
2-fluoroisonicotinic acid
→
O=C(O)c1ccncc1Nc1ccc(I)cc1Cl
3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid

Reactants

Nc1ccc(I)cc1Cl
2-chloro-4-iodoaniline
O=C(O)c1ccnc(F)c1
2-fluoroisonicotinic acid

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherSynthesized as intermediate 1
  2. 2
    Other5.9 min

Procedure

Synthesized as intermediate 1 by reacting 15.7 mmol of 2-chloro-4-iodoaniline with 23.55 mmol 2-fluoroisonicotinic acid. LC/MS [(5.9 min; 376 (M+1)].

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524911B2uspto-grants-2013_09