Reaction #674342

ord-a0736a39bbef4fe98b9f93c1777ccad5

Reaction equation

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
c1ccc(CCC2CCCN2)cc1
rac-2-(2-phenylethyl)pyrrolidine
→
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCC3CCc3ccccc3)n2)c1
rac-3-[(4-(2-(2-Phenylethyl)pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

Reactants

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
c1ccc(CCC2CCCN2)cc1
rac-2-(2-phenylethyl)pyrrolidine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherB27 was prepared
  2. 2
    Otherobtained as a white crystalline solid

Procedure

B27 was prepared following the procedure reported for B4 using A1 and rac-2-(2-phenylethyl)pyrrolidine and obtained as a white crystalline solid; yield: 140 mg (35%). MS (ES) C22H26N6O2S requires: 438. found: 439 (M+H)+.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09226929B2uspto-grants-2016_01