Reaction #674339

ord-25eef63aa56446f98eafef42343edcdd

Reaction equation

NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
B1
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
3-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamide
OC[C@H]1CCCN1
(R)-2-(hydroxymethyl)pyrrolidine
→
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCC[C@@H]3CO)n2)c1
(R)-3-[(4-(2-(Hydroxymethyl)pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

Reactants

NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
B1
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
3-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamide
OC[C@H]1CCCN1
(R)-2-(hydroxymethyl)pyrrolidine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherB24 was prepared

Procedure

B24 was prepared following the procedure reported for B1 using Al and (R)-2-(hydroxymethyl)pyrrolidine. MS (ES) C15H20N6O3S requires: 364. found: 365 (M+H)+.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09226929B2uspto-grants-2016_01