Reaction #6710

Reaction equation

N-Methyl-piperidine-2-carboxylic acid ethyl ester

NaOH

hydrochloric acid

→

N-methyl-piperidine-2-carboxylic acid

Solvents

methanol

water

Conditions

Workup

1. 1
   Otherevaporated to dryness
2. 2
   Otherevaporated four times with toluene

Procedure

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

Source