Reaction #670220

Reaction equation

(3,3-diethoxy-2-oxopropylidene)(triphenyl)phosphorane

4-chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole

→

crude product

4-Chloro-3-[4-chloro-3-(4,4-diethoxy-3-oxobut-1-en1-yl)phenyl]-5-difluoromethoxy-1-methyl-1H-pyrazole

Solvents

dimethylformamide

Conditions

Workup

1. 1
   ConcentrationThe mixture was then concentrated

Procedure

5.1 g of (3,3-diethoxy-2-oxopropylidene)(triphenyl)phosphorane were added to a solution of 2 g (6.2 mmol) of 4-chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 20 ml of dimethylformamide, and the mixture was hen heated at 80-90° C. for 5 hours. The mixture was then concentrated and the crude product thus obtained was purified by chromatography on silica gel (eluent: hexane/ethyl acetate=4:1). Yield: 2.1 g.

Source